A technique for approximating transition rates from published survival analyses
نویسندگان
چکیده
منابع مشابه
Computing exact excess death rates from a published mortality study.
We wish to estimate the associated excess death rate (EDR) or mortality ratio (MR) from a published study of persons with a given medical condition. This requires computation of the expected mortality in the study population. If age- and sex-specific person years of data are available, this task is straightforward. Most often, however, we have only descriptive statistics--percentage male, avera...
متن کاملSurrogacy of progression free survival for overall survival in metastatic breast cancer studies: Meta-analyses of published studies.
PURPOSE PFS is often used as a surrogate endpoint for OS in metastatic breast cancer studies. We have evaluated the association of treatment effect on PFS with significant HROS (and how this association is affected by other factors) in published prospective metastatic breast cancer studies. METHODS A systematic literature search in PubMed identified prospective metastatic breast cancer studie...
متن کاملCalculating transition rates from durations of transition paths.
Calculating the kinetic rates for rare transitions is an important objective for molecular simulations. Here I prove equalities that relate the transition rates to the equilibrium free energy and the statistics of the transition paths. In particular, the durations of the transition paths within given intervals of the reaction coordinate provide the kinetic pre-factor in the rate formula. Based ...
متن کاملEstimating multistate transition rates from population distributions
The ability to estimate interstate transition rates (or probabilities) from population distributions has many potential applications in demography. Iterative Proportional Fitting (IPF) has been used for such estimation, but lacks a meaningful behavioral foundation. Here a new approach, Relative State Attraction (RSA), is advanced. It assumes that states have a greater (or lesser) ability to att...
متن کاملReaction coordinates and rates from transition paths.
The molecular mechanism of a reaction in solution is reflected in its transition-state ensemble and transition paths. We use a Bayesian formula relating the equilibrium and transition-path ensembles to identify transition states, rank reaction coordinates, and estimate rate coefficients. We also introduce a variational procedure to optimize reaction coordinates. The theory is illustrated with a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cost Effectiveness and Resource Allocation
سال: 2019
ISSN: 1478-7547
DOI: 10.1186/s12962-019-0182-7